Rutin Therapy Role in Reducing Ulcerative Colitis Severity

Summary

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications. A key player in the inflammation process is the NLRP3 inflammasome. This inflammasome's expression is heightened and activated by reactive oxygen species (ROS). Its activity is influenced by various factors, including the ubiquitin system, ion channels, and gut microbiota. Rutin, a compound found in many fruits and vegetables, has been shown to have properties that help scavenge free radicals.

Timeline

Start

2024-11-01

Primary completion

2025-01-08

Completion

2025-05-20

Drugs

Indications