Efficacy and Mechanism of FMT in the Treatment of Inflammatory Bowel Disease: an Open-label Randomized Controlled Study

Summary

This study enrolled 94 patients with UC or CD. Two groups received either 8-week intestinal bacterial transplant capsule therapy or biological therapy, respectively. The control group received biological therapy alone, while the experimental group received biological therapy combined with FMT. Both groups were followed up for 52 weeks after discharge. The efficacy of FMT capsule therapy on the subjects' UC or CD symptom-related scores and its effect on remodeling the intestinal flora were observed, and its safety was verified.

Timeline

Start

2025-08-01

Primary completion

2028-09-01

Completion

2028-09-01

Publications

• Wang X, Wu W, Yang B, Liu Y, Xu Y, Wang L, Lv X, Gao J, Lu M, Yu A, Li N, Chen Q, Lu L, Zhao D. Additive effects of fecal microbiota transplantation and infliximab on gut microbiome and metabolome in refractory inflammatory bowel disease patients. mSystems. 2026 Apr 21;11(4):e0077425. doi: 10.1128/msystems.00774-25. Epub 2026 Mar 23.

Drugs

Indications