drugset / Trial / NCT07168343
Effectiveness of Two Icodextrin Exchanges on Fluid Status and Blood Pressure Control Compared to a Single Icodextrin Exchange
Not yet recruiting
10 enrolled
National University Health System, Singapore
Children's Hospital of Fudan University · collabPhilippine Children's Medical Center · collabThe UCL Great Ormond Street Institute of Child Health · collab
RandomizedCrossoverOpen-labelTreatment
Summary
Fluid overload and hypertension are prevalent in children undergoing chronic peritoneal dialysis (PD), especially in low- and middle-income countries (LMICs). These complications often lead to increased hospitalizations, higher medication use, and, in some cases, conversion to hemodialysis. Icodextrin is used to enhance ultrafiltration (UF) and reduce glucose exposure, but its effectiveness in children with a single long dwell has been inconsistent. Preliminary observations suggest that shorter, twice-daily icodextrin exchanges may improve UF and blood pressure (BP) control. However, no randomized trial has evaluated this approach in pediatric patients.
Timeline
- Start
- 2026-02-28
- Primary completion
- 2028-06-30
- Completion
- 2028-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Icodextrin | Other / unclassified | 550 unknown | — |
Indications
No indication recorded.