drugset / Trial / NCT07181109

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

NCT07181109

Phase 3 Recruiting 11000 enrolled Alnylam Pharmaceuticals Hoffmann-La Roche · collab
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.

Timeline

Start
2025-09-22
Primary completion
2030-09-30
Completion
2030-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Zilebesiran Unknown 300 mg Subcutaneous