drugset / Trial / NCT07181720
CD70-Targeted CAR-T Therapy in CD70-Positive Advanced Solid Tumors
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CD70-targeted CAR-T cell preparations, and to preliminarily observe the study drug in CD70-positive advanced malignant tumors. The pharmacokinetic characteristics of CAR-T cell preparations for the treatment of patients with CD70-positive advanced malignancies were obtained and the recommended dose and infusion schedule.
Timeline
- Start
- 2025-09-12
- Primary completion
- 2028-03-31
- Completion
- 2028-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | CD70-targeted CAR-T cells | Cell therapy | 300000 cells/kg | Other |
| Subject | CD70-targeted CAR-T cells | Cell therapy | 1e+06 cells/kg | Other |