Zanzalintinib for Advanced Urothelial Carcinoma Progressing After Prior Therapy

Summary

This is a Phase II, single arm study. All subjects will receive Zanzalintinib 60 mg orally once daily until progression per RECIST 1.1 or intolerable toxicities or patient/investigator decision to discontinue study therapy. Radiology imaging will be performed every 8 weeks for 3 timepoints then every 12 weeks thereafter. A window of ± 7 days may be applied to all study visits to accommodate observed holidays, inclement weather, scheduling conflicts etc.

Timeline

Start

2026-06

Primary completion

2027-06

Completion

2029-06

Drugs

Indications