i-PRF & Root Surface Biomodification

Summary

This study is designed to evaluate a new method to improve healing in patients with gum disease (periodontitis). A total of 42 adults with gum pockets deeper than 5 millimeters will take part. All patients will undergo flap surgery, which is a standard treatment for gum disease. Half of the patients will also receive an additional treatment with injectable platelet-rich fibrin (i-PRF), made from their own blood, together with root surface cleaning using EDTA gel. Patients will be followed for 6 months. The study will measure changes in gum pocket depth, gum attachment to teeth, and healing.

Timeline

Start

2023-02-01

Primary completion

2024-06-28

Completion

2024-06-28

Publications

• Bicakcioglu HA, Kurtis MB. Open flap debridement with EDTA-conditioned root surface biomodification with or without injectable platelet-rich fibrin: a randomized controlled trial. BMC Oral Health. 2026 Apr 22;26(1):821. doi: 10.1186/s12903-026-08324-4.

Drugs

Indications