drugset / Trial / NCT07225777
Sex Differences in Neurobehavioral Response to THC
Phase 2
Terminated
5 enrolled
Medical University of South Carolina
National Institute on Drug Abuse (NIDA) · collabNational Institutes of Health (NIH) · collab
RandomizedCrossoverDouble-blindBasic science
Summary
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Timeline
- Start
- 2026-04-27
- Primary completion
- 2026-08-31
- Completion
- 2026-08-31
Outcome
Outcome not reported
Stopped (Business): “Funding status change.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dronabinol | Other / unclassified | 40 mg | Oral |