drugset / Trial / NCT07227402

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

NCT07227402

Phase 3 Recruiting 904 enrolled Merck Sharp & Dohme LLC Exelixis · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

Researchers are looking for more ways to treat advanced renal cell carcinoma (RCC) that is recurrent. Researchers want to learn if recurrent advanced renal cell carcinoma (RCC) responds (gets smaller or goes away) after treatment with belzutifan (MK-6482) and zanzalintinib compared to cabozantinib. The goal of this study is to learn if: People who take belzutifan and zanzalintinib live longer overall and without the cancer getting worse than people who take cabozantinib.

Timeline

Start
2025-11-26
Primary completion
2032-02-27
Completion
2032-02-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Belzutifan Small molecule Oral
Comparator Cabozantinib Small molecule Oral
Subject Zanzalintinib Small molecule Oral

Indications