A Double-blind Non Inferiority Clinical Trial to Compare the Nephroprotection of Cilastatn Versus Thiosulfate in Patients Undergoing Debulking Surgery With Intraoperative Hyperthermic Intraperitoneal Chemotherapy With Cisplatin.

Phase 2 Recruiting 90 enrolled Hospital General Universitario Gregorio Marañon

RandomizedParallel-groupTriple-blindTreatment

Summary

To compare cilastatin vs thiosulfatein renal protection in patients undergoing debulking surgery with intraoperative hyperthermic intraperitoneal chemotherapy with cisplatin

Timeline

Start: 2025-02-21
Primary completion: 2028-10-21
Completion: 2028-10-21

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cilastatin	Small molecule	1.5 g	—
Comparator	tiosulfate	Unknown	—	—

A Double-blind Non Inferiority Clinical Trial to Compare the Nephroprotection of Cilastatn Versus Thiosulfate in Patients Undergoing Debulking Surgery With Intraoperative Hyperthermic Intraperitoneal Chemotherapy With Cisplatin.

Summary

Timeline

Drugs

Indications