drugset / Trial / NCT07263425
Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Trastuzumab in Breast Cancer With Leptomeningeal Metastasis
Phase 2
Recruiting
26 enrolled
The First Affiliated Hospital with Nanjing Medical University
The Affiliated Brain Hospital of Nanjing Medical University · collab
NaSingle-groupOpen-labelTreatment
Summary
Evaluate the efficacy and safety of Intrathecal Administration of Thiotepa in Combination with Trastuzumab via the Ommaya Reservoir in Breast Cancer with Leptomeningeal Metastasis
Timeline
- Start
- 2025-10-27
- Primary completion
- 2027-10-27
- Completion
- 2027-10-27
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Thiotepa | Other / unclassified | 10 mg | Intrathecal |
| Subject | Trastuzumab | Monoclonal antibody | 150 mg | Intrathecal |