Immune Tolerance Induction After Liver Transplantation

Summary

This clinical trial is being conducted to help liver transplant recipients safely discontinue toxic immunosuppressive drugs years after surgery. Lifelong use of these drugs is the current standard, but they come with life-threatening side effects. UCLA has pioneered this "Delayed Tolerance" approach, achieving success in numerous kidney recipients now living drug-free. The process uses a conditioning regimen followed by donor stem cell infusion to retrain the immune system to accept the liver as "self."

Timeline

Start

2026-02-20

Primary completion

2029-01

Completion

2033-01

Publications

• Background Nassiri N, Lum E, Mead MD, Raldow AC, Kogut N, Veale JL. Immune tolerance induction through haematopoietic chimerism after kidney donation. Lancet. 2022 Aug 6;400(10350):e2. doi: 10.1016/S0140-6736(22)00914-X. No abstract available.
• Background Lum EL, Nassiri N, Kogut N, Oliai C, Raldow A, Reed EF, Veale JL. Delayed immune tolerance through donor haematopoietic stem cell infusion 14 months after kidney transplantation. Lancet. 2024 Oct 5;404(10460):1346. doi: 10.1016/S0140-6736(24)01935-4. No abstract available.

Drugs

Indications