Nicardipine vs. Labetalol

Summary

In this ED-based study, the investigators compared the time to reach target blood pressure (BP) between hypertensive patients with acute ischemic stroke (AIS) undergoing intravenous (IV) thrombolysis and/or mechanical thrombectomy who received IV nicardipine versus labetalol. Additionally, the investigators evaluated the rate of early neurological improvement (ENI), length of hospital stay (LOS), in-hospital mortality, and adverse event profiles between the two treatment groups.

Timeline

Start

2025-02-01

Primary completion

2025-07-01

Completion

2025-08-01

Publications

• Results Guo QH, Liu CH, Wang JG. Blood Pressure Goals in Acute Stroke. Am J Hypertens. 2022 Jun 16;35(6):483-499. doi: 10.1093/ajh/hpac039.
• Results Huang A, Parker D Jr, Wein R. Comparison of nicardipine versus labetalol for time to alteplase administration in acute ischemic stroke. Front Neurol. 2025 Jul 2;16:1573352. doi: 10.3389/fneur.2025.1573352. eCollection 2025.
• Results Hao F, Yin S, Tang L, Zhang X, Zhang S. Nicardipine versus Labetalol for Hypertension during Acute Stroke: A Systematic Review and Meta-Analysis. Neurol India. 2022 Sep-Oct;70(5):1793-1799. doi: 10.4103/0028-3886.359214.
• Results Ortega-Gutierrez S, Thomas J, Reccius A, Agarwal S, Lantigua H, Li M, Carpenter AM, Mayer SA, Schmidt JM, Lee K, Claassen J, Badjatia N, Lesch C. Effectiveness and safety of nicardipine and labetalol infusion for blood pressure management in patients with intracerebral and subarachnoid hemorrhage. Neurocrit Care. 2013 Feb;18(1):13-9. doi: 10.1007/s12028-012-9782-1.

Drugs

Indications