drugset / Trial / NCT07282574

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)

NCT07282574

Phase 2 Recruiting 360 enrolled Hoffmann-La Roche
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The main purpose of this study is to assess the efficacy of RO7268489 in adults with progressive multiple sclerosis (PMS) receiving ocrelizumab. After the end of the double-blind period, an open-label (OL) extension may allow eligible participants to receive open-label RO7268489.

Timeline

Start
2026-03-10
Primary completion
2028-05-30
Completion
2030-05-30

Drugs

EvaluationDrugModalityDoseRoute
Subject RO7268489 Unknown
Background Ocrelizumab Monoclonal antibody

Indications