drugset / Trial / NCT07283770
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single dose of VX-581 and multiple ascending doses of VX-581 alone and in combination with tezacaftor (TEZ)/deutivacaftor (D-IVA) or D-IVA for up to ten days.
Timeline
- Start
- 2025-12-09
- Primary completion
- 2026-11-19
- Completion
- 2026-11-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | VX-581 | Unknown | — | Oral |
| Background | D-IVA | Unknown | — | Oral |
| Background | TEZ | Unknown | — | Oral |