drugset / Trial / NCT07288749
Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.
Phase 3
Not yet recruiting
1484 enrolled
Tongji Hospital
Anhui Provincial Hospital · collabBeijing Anzhen Hospital · collabChinese Academy of Medical Sciences, Fuwai Hospital · collabFirst Affiliated Hospital of Xinjiang Medical University · collabFirst Hospital of China Medical University · collabHuaxi Hospital · collabNanjing Medical University · collabSecond Xiangya Hospital of Central South University · collabShanghai Zhongshan Hospital · collabSouthwest Medical University · collabThe First Affiliated Hospital of Air Force Medicial University · collabThe First Affiliated Hospital of Zhengzhou University · collabTianjin Medical University · collabWuhan Central Hospital · collabXiangya Hospital · collabZhongnan Hospital · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.
Timeline
- Start
- 2026-01-01
- Primary completion
- 2030-12-31
- Completion
- 2031-12-31
Publications
- Results Karwi QG, Ho KL, Pherwani S, Ketema EB, Sun Q, Lopaschuk GD. Corrigendum to: Concurrent diabetes and heart failure: interplay and novel therapeutic approaches. Cardiovasc Res. 2022 Jun 22;118(7):1850. doi: 10.1093/cvr/cvab355. No abstract available.
- Results Fitchett DH, Udell JA, Inzucchi SE. Heart failure outcomes in clinical trials of glucose-lowering agents in patients with diabetes. Eur J Heart Fail. 2017 Jan;19(1):43-53. doi: 10.1002/ejhf.633. Epub 2016 Sep 21.
- Results He W, Yuan G, Han Y, Yan Y, Li G, Zhao C, Shen J, Jiang X, Chen C, Ni L, Wang DW. Glimepiride Use is Associated with Reduced Cardiovascular Mortality in Patients with Type 2 Diabetes and Chronic Heart Failure: A Prospective Cohort Study. Eur J Prev Cardiol. 2022 Dec 27:zwac312. doi: 10.1093/eurjpc/zwac312. Online ahead of print.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glimepiride | Small molecule | 2 mg | Oral |
| Subject | Glimepiride | Small molecule | 4 mg | Oral |