Effect of i-PRF and LLLT on Free Gingival Graft Shrinkage

Summary

This randomized clinical trial aims to evaluate whether injectable platelet-rich fibrin (i-PRF) and low-level laser therapy (LLLT) can reduce graft shrinkage after free gingival graft procedures. Free gingival grafts are commonly used to increase the width of keratinized tissue around teeth, but the graft often shrinks during healing. In this study, patients will receive standard free gingival graft surgery with or without additional i-PRF or laser therapy. The goal is to determine whether these treatments improve healing and help maintain the size of the graft.

Timeline

Start

2024-07-01

Primary completion

2025-08-30

Completion

2025-08-30

Publications

• Background Shakiliyeva S, Sahin D, Gunpinar S, Gursel M. Comparison of conventional and modified sling suture techniques in free gingival graft operations-a randomized controlled clinical trial. BMC Oral Health. 2025 Feb 21;25(1):279. doi: 10.1186/s12903-025-05456-x.
• Bozkurt E, Ozdemir EC. The Effect of injectable platelet-rich fibrin and low-level laser therapy on graft shrinkage in free gingival grafts: a randomized controlled clinical trial. BMC Oral Health. 2026 Apr 13;26(1):990. doi: 10.1186/s12903-026-08309-3.

Drugs

Indications