drugset / Trial / NCT07310628
Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study
Phase 4
Completed
64 enrolled
All India Institute of Medical Sciences
All India Institute of Medical Sciences, Raebareli, UP · collab
RandomizedCrossoverDouble-blindPrevention
Summary
Tizanidine, alpha-2 adrenergic receptor agonist, provides analgesic and hemodynamic benefits, which could enhance the efficacy of local anaesthetics. This randomized controlled trial examines the effectiveness of oral tizanidine as an adjunct to intrathecal levobupivacaine for spinal anaesthesia in lower limb surgeries
Timeline
- Start
- 2022-08-20
- Primary completion
- 2025-07-10
- Completion
- 2025-08-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tizanidine | Small molecule | 4 mg | Oral |