drugset / Trial / NCT07314489

A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis

NCT07314489

Phase 0 Recruiting 80 enrolled Shanghai Changzheng Hospital
NaSingle-groupOpen-labelPrevention

Summary

This study aims to investigate the impact of pancreatic exocrine insufficiency on the glucose profile and pancreatic and gastrointestinal endocrine hormones in patients with chronic pancreatitis through pancreatic enzyme intervention in a reverse manner. The primary objective is to observe the changes in glucose profile following pancreatic enzyme intervention in patients with chronic pancreatitis complicated by exocrine insufficiency and normal glucose metabolism. The secondary objective is to observe the changes in pancreatic endocrine and exocrine functions and gastrointestinal endocrine hormone levels following pancreatic enzyme intervention in patients with chronic pancreatitis complicated by exocrine insufficiency and normal glucose metabolism.

Timeline

Start
2025-04-01
Primary completion
2026-12-31
Completion
2035-12-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Pancrelipase Protein / enzyme biologic 0.3 g

Indications