Effect of Drospirenone-Ethinyl Estradiol (20microgram vs 30 Microgram) on Free Androgen Index in PCOS

Summary

Combined hormonal contraceptive (CHC) improves androgen parameter in women with PCOS. High-dose CHC increases insulin resistance, whereas low dose CHC has minimal effects on carbohydrate metabolism. This quasi experimental study was conducted to compare the effects of Drospirenone-Ethinyl Estradiol (20µg) to that with Drospirenone-Ethinyl Estradiol (30µg) on free androgen index (FAI) in polycystic ovary syndrome. Medication was given for 3 months. FAI, HOMA-IR was measured in baseline and after treatment and results were compared.

Timeline

Start

2024-07-01

Primary completion

2025-06-30

Completion

2025-06-30

Publications

• Results Rajashekar S, Giri Ravindran S, Kakarla M, Ausaja Gambo M, Yousri Salama M, Haidar Ismail N, Tavalla P, Uppal P, Mohammed SA, Hamid P. Spironolactone Versus Oral Contraceptive Pills in the Treatment of Adolescent Polycystic Ovarian Syndrome: A Systematic Review. Cureus. 2022 May 25;14(5):e25340. doi: 10.7759/cureus.25340. eCollection 2022 May.
• Results Bhattacharya SM, Jha A, DasMukhopadhyay L. Comparison of two contraceptive pills containing drospirenone and 20 mug or 30 mug ethinyl estradiol for polycystic ovary syndrome. Int J Gynaecol Obstet. 2016 Feb;132(2):210-3. doi: 10.1016/j.ijgo.2015.06.065. Epub 2015 Nov 6.

Drugs

Indications