drugset / Trial / NCT07357935
Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
Phase 1/2
Not yet recruiting
500 enrolled
Qingyuan Zhan
The First Affiliated Hospital of Guangzhou Medical University · collabWuhan Metware Biotechnology Co., Ltd. · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF). The study focuses on bacterial CAP-ARF patients receiving standardized glucocorticoid therapy to investigate the heterogeneity of treatment responses under different etiologies and immune statuses. The goal is to provide a data foundation for precise immune stratification and identification of glucocorticoid-sensitive populations.
Timeline
- Start
- 2026-02-01
- Primary completion
- 2028-09-01
- Completion
- 2028-10-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methylprednisolone | Other / unclassified | 0.5 mg/kg | Intravenous |
| Subject | Methylprednisolone | Other / unclassified | 1 mg/kg | Intravenous |