drugset / Trial / NCT07361263
Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency
RandomizedCrossoverTriple-blindDiagnostic
Summary
The PHOENIX study aims to investigate whether oral estradiol valerate (EV) and ethinylestradiol (EE) can stimulate oxytocin (OXT) and neurophysin-1 (NP-1) release in humans. The goal is to assess their potential as a safe diagnostic stimulation test for oxytocin deficiency, particularly in patients with arginine vasopressin (AVP) deficiency.
Timeline
- Start
- 2026-01-09
- Primary completion
- 2027-02
- Completion
- 2027-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | estradiol valerate | Unknown | — | Oral |
| Subject | ethinyl estradiol | Small molecule | — | Oral |