drugset / Trial / NCT07363486

Sequential Study of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT07363486

Non-randomizedSequentialOpen-labelTreatment

Summary

PSMA is an ideal target for the precise diagnosis and treatment of prostate cancer. LNC1011 is a novel albumin-binding PSMA-targeted compound. This study aims to investigate the safety and efficacy of different doses of 225Ac-labeled LNC1011 in the treatment of patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) and to explore the optimal therapeutic dose.

Timeline

Start
2025-04-01
Primary completion
2026-12-31
Completion
2027-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject 225Ac-LNC1011 Other / unclassified 3.7 mbq Intravenous
Subject 225Ac-LNC1011 Other / unclassified 5.55 mbq Intravenous
Subject 225Ac-LNC1011 Other / unclassified 7.4 mbq Intravenous

Indications