drugset / Trial / NCT07363486
Sequential Study of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer
Non-randomizedSequentialOpen-labelTreatment
Summary
PSMA is an ideal target for the precise diagnosis and treatment of prostate cancer. LNC1011 is a novel albumin-binding PSMA-targeted compound. This study aims to investigate the safety and efficacy of different doses of 225Ac-labeled LNC1011 in the treatment of patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) and to explore the optimal therapeutic dose.
Timeline
- Start
- 2025-04-01
- Primary completion
- 2026-12-31
- Completion
- 2027-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 225Ac-LNC1011 | Other / unclassified | 3.7 mbq | Intravenous |
| Subject | 225Ac-LNC1011 | Other / unclassified | 5.55 mbq | Intravenous |
| Subject | 225Ac-LNC1011 | Other / unclassified | 7.4 mbq | Intravenous |