Etoricoxib in Patients With Parkinsonian Disease

Summary

Neuroinflammation is considered one of the most important factors contributing critically to pathophysiology of PD . Recently, high mobility group box-1 (HMGB1) protein has been encoded as a potential inflammatory biomarker in PD. HMGB1 mediates immune response mostly through endothelial cells and macrophage activation via targeting two vital cell receptors; Toll-like receptor 4 (TLR4) and advanced glycation end products (RAGE).

Timeline

Start

2026-01-30

Primary completion

2027-11-10

Completion

2027-11-20

Drugs

Indications