Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device

Summary

In this study, we evaluated the extent of reversal of facial dermal aging signs using topical lyophilized exosomes with a microneedling device

Timeline

Start

2024-07-01

Primary completion

2024-12-01

Completion

2025-03-01

Publications

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• Results Shin KO, Ha DH, Kim JO, Crumrine DA, Meyer JM, Wakefield JS, Lee Y, Kim B, Kim S, Kim HK, Lee J, Kwon HH, Park GH, Lee JH, Lim J, Park S, Elias PM, Park K, Yi YW, Cho BS. Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. Cells. 2020 Mar 10;9(3):680. doi: 10.3390/cells9030680.
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• Results Liu M, Wang H, Liu Z, Liu G, Wang W, Li X. Exosomes from adipose-derived stem cells inhibits skin cancer progression via miR-199a-5p/SOX4. Biotechnol Genet Eng Rev. 2024 Dec;40(4):3950-3962. doi: 10.1080/02648725.2023.2204702. Epub 2023 Apr 24.
• Results Lueangarun S, Cho BS, Tempark T. Topical moisturizer with rose stem cell-derived exosomes (RSCEs) for recalcitrant seborrheic dermatitis: A case report with 6 months of follow-up. J Cosmet Dermatol. 2024 Oct;23(10):3128-3132. doi: 10.1111/jocd.16389. Epub 2024 Jun 3.
• Results Hade MD, Suire CN, Suo Z. Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine. Cells. 2021 Aug 1;10(8):1959. doi: 10.3390/cells10081959.
• Results Ha DH, Kim HK, Lee J, Kwon HH, Park GH, Yang SH, Jung JY, Choi H, Lee JH, Sung S, Yi YW, Cho BS. Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration. Cells. 2020 May 7;9(5):1157. doi: 10.3390/cells9051157.
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• Results Eiben-Nielson C, Kerscher M. Development and validation of a global photonumeric scale for evaluating skin quality of aged female facial skin. J Cosmet Dermatol. 2021 Dec;20(12):4032-4039. doi: 10.1111/jocd.14058. Epub 2021 Mar 24.
• Results Rorteau J, Chevalier FP, Fromy B, Lamartine J. [Functional integrity of aging skin, from cutaneous biology to anti-aging strategies]. Med Sci (Paris). 2020 Dec;36(12):1155-1162. doi: 10.1051/medsci/2020223. Epub 2020 Dec 9. French.
• Results Csekes E, Rackova L. Skin Aging, Cellular Senescence and Natural Polyphenols. Int J Mol Sci. 2021 Nov 23;22(23):12641. doi: 10.3390/ijms222312641.
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