Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases

Phase 2 Not yet recruiting 30 enrolled Affiliated Hospital of Nantong University

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether poly（β-amino ester）(PAE)hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes(tRF-ASO-Exo) could alleviate symptoms in patients with diabetic ocular surface diseases(DOSD).

Timeline

Start: 2026-02-15
Primary completion: 2028-12-30
Completion: 2029-06-30

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Exosomes	Other / unclassified	10 ug	—
Subject	tRF-ASO-Exo	Unknown	10 ug	—
Subject	tRF-ASO-Exo-PAE	Unknown	10 ug	Topical

Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases

Summary

Timeline

Drugs

Indications