drugset / Trial / NCT07389590
Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis
RandomizedParallel-groupSingle-blindTreatment
Summary
The proposed study is a pilot study of ublituximab involving people with multiple sclerosis (MS) who are experiencing a "wearing off" phenomenon (return or worsening of MS-related symptoms) while being treated with ocrelizumab, and exploring whether switching to ublituzimab can resolve, improve or delay this phenomenon.
Timeline
- Start
- 2026-02-10
- Primary completion
- 2028-10
- Completion
- 2029-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ocrelizumab | Monoclonal antibody | 600 mg | Intravenous |
| Subject | Ublituximab | Monoclonal antibody | 450 mg | Intravenous |