drugset / Trial / NCT07389590

Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis

NCT07389590

RandomizedParallel-groupSingle-blindTreatment

Summary

The proposed study is a pilot study of ublituximab involving people with multiple sclerosis (MS) who are experiencing a "wearing off" phenomenon (return or worsening of MS-related symptoms) while being treated with ocrelizumab, and exploring whether switching to ublituzimab can resolve, improve or delay this phenomenon.

Timeline

Start
2026-02-10
Primary completion
2028-10
Completion
2029-03

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ocrelizumab Monoclonal antibody 600 mg Intravenous
Subject Ublituximab Monoclonal antibody 450 mg Intravenous

Indications