drugset / Trial / NCT07392814
Study With Tocilizumab in Combination With Venetoclax and Azacitidine Chemotherapy in Patients With Acute Myeloid Leukemia
NaSingle-groupOpen-labelTreatment
Summary
This is a phase 1, open label, interventional, single center, in patients with Acute Myeloid Leukemia (AML). This study will investigate dose escalation of tocilizumab in combination with venetoclax and azacitidine chemotherapy. The patient population will consist of adults men and women at least 18 years, who meet eligibility criteria. In this study propose combining tocilizumab with the standard treatment of azacitidine and venetoclax for patients with AML who are not eligible for intensive treatment.
Timeline
- Start
- 2026-03-10
- Primary completion
- 2028-07-10
- Completion
- 2030-07-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tocilizumab | Monoclonal antibody | 4 mg/kg | — |
| Subject | Tocilizumab | Monoclonal antibody | 6 mg/kg | — |
| Subject | Tocilizumab | Monoclonal antibody | 8 mg/kg | — |