drugset / Trial / NCT07392814

Study With Tocilizumab in Combination With Venetoclax and Azacitidine Chemotherapy in Patients With Acute Myeloid Leukemia

NCT07392814

Phase 1 Not yet recruiting 12 enrolled Nantes University Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is a phase 1, open label, interventional, single center, in patients with Acute Myeloid Leukemia (AML). This study will investigate dose escalation of tocilizumab in combination with venetoclax and azacitidine chemotherapy. The patient population will consist of adults men and women at least 18 years, who meet eligibility criteria. In this study propose combining tocilizumab with the standard treatment of azacitidine and venetoclax for patients with AML who are not eligible for intensive treatment.

Timeline

Start
2026-03-10
Primary completion
2028-07-10
Completion
2030-07-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Tocilizumab Monoclonal antibody 4 mg/kg
Subject Tocilizumab Monoclonal antibody 6 mg/kg
Subject Tocilizumab Monoclonal antibody 8 mg/kg