drugset / Trial / NCT07444827

Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches

NCT07444827

Phase 4 Not yet recruiting 25 enrolled Duke University
RandomizedCrossoverTriple-blindBasic science

Summary

This randomized, double-blinded volunteer study compares two ways of performing the adductor canal (AC) nerve block at the mid-thigh to see which approach more reliably numbs the anteromedial knee. One approach is the traditional AC block placed near the saphenous nerve; the other separately targets the nerve to vastus medialis (NVM) in addition to the saphenous nerve. Healthy adult participants receive both blocks in one visit (one on each leg), with the order randomized. The primary outcome is change in quadriceps strength (a proxy for vastus medialis anesthesia) measured by load-cell dynamometry. Secondary outcomes include cutaneous sensory mapping (pinprick and cold) and the percentage of a standardized, marked knee-incision line covered by sensory block. The study uses ultrasound guidance and a standard dose of chloroprocaine, with routine monitoring to minimize risks.

Timeline

Start
2026-07-01
Primary completion
2027-07-01
Completion
2027-12-01

Drugs

EvaluationDrugModalityDoseRoute
Background Chloroprocaine Other / unclassified 2 % Other

Indications

No indication recorded.