Rct Assessing Pregnancy - Piroxicam for Ec With Levonorgestrel

Phase 3 Not yet recruiting 1458 enrolled University of Utah

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This randomized controlled trial will test oral levonorgestrel + piroxicam vs. levonorgestrel + placebo for emergency contraception in a representative U.S. population that has higher pregnancy risk than in the prior study because of higher weights, different intercourse patterns, and different clinic accessibility. Data from this project will inform clinical practice in the U.S. and beyond for those desiring the most effective method of emergency contraception pills.

Timeline

Start: 2027-03
Primary completion: 2031-06
Completion: 2031-11

Publications

Background Li RHW, Lo SST, Gemzell-Danielsson K, Fong CHY, Ho PC, Ng EHY. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023 Sep 9;402(10405):851-858. doi: 10.1016/S0140-6736(23)01240-0. Epub 2023 Aug 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Piroxicam	Unknown	40 mg	Oral
Background	Levonorgestrel	Small molecule	1.5 mg	Oral

Indications

No indication recorded.