Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1

Phase 0 Recruiting 32 enrolled Yale University National Institute of Mental Health (NIMH) · collab

Non-randomizedParallel-groupOpen-labelOther

Summary

Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.

Timeline

Start: 2026-04
Primary completion: 2030-01
Completion: 2030-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	[ 18F]GATT-44	Unknown	—	—

Indications

No indication recorded.