Influence of Hyaluronic Acid in the Healing of Palatal Donor Sites During Free Gingival Graft Procedures

Completed 20 enrolled University of Milan Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The goal of this study is to evaluate the use of a gel containing cross-linked hyaluronic acid (xHyA) at the palatal donor site following soft tissue harvesting procedures. The main questions it aims to answer are: 1) Does the use of xHyA improve post-operative patient morbidity?; 2) Does the use of xHyA improve palatal donor site healing? Researchers will compare xHyA topically applied at the palatal donor site to a negative control to see if xHyA works to minimize participants' morbidity and improve clinical healing. Participants will be equally distributed into two groups, half of them receiving xHyA. Participants will fill a visual analogue scale for subjective analyses during the first 2 post-operative weeks and will visit the dental clinic at 3, 7, 14 and 60 post-operative days for checkups and clinical examinations.

Timeline

Start: 2022-09-05
Primary completion: 2025-07-24
Completion: 2025-10-02

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	xHyA	Unknown	1.2 ml	—

Indications

No indication recorded.