Objective Evaluation of Intradermal MSC-Derived Exosome Therapy on Facial Skin Quality

Summary

This study aims to evaluate the potential effects of mesenchymal stem cell-derived suspended exosome therapy on facial skin quality using objective imaging analysis. Thirty adult participants will receive intradermal exosome applications in three treatment sessions performed at one-month intervals. Facial skin analysis will be conducted using the VISIA imaging system before each treatment session and six months after the final treatment. The study will examine changes in multiple facial skin characteristics including wrinkles, pigmentation, skin texture, pores, UV spots, red areas, brown spots, and porphyrins to determine whether exosome therapy may improve overall facial skin quality.

Timeline

Start

2026-04-01

Primary completion

2026-12-01

Completion

2026-12-31

Publications

• Background Wyles SP, Proffer SL, Farris P, Randall L, Hillestad ML, Lupo MP, Behfar A. Effect of Topical Human Platelet Extract (HPE) for Facial Skin Rejuvenation: A Histological Study of Collagen and Elastin. J Drugs Dermatol. 2024 Sep 1;23(9):735-740. doi: 10.36849/JDD.8162.
• Background Proffer SL, Paradise CR, DeGrazia E, Halaas Y, Durairaj KK, Somenek M, Sivly A, Boon AJ, Behfar A, Wyles SP. Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results. Aesthet Surg J. 2022 Sep 14;42(10):1185-1193. doi: 10.1093/asj/sjac149.

Drugs

Indications

No indication recorded.