The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

Recruiting 44 enrolled University of Reading eBeauty Ltd Innopure, Regus House, Cardiff Gate Business Park, Malthouse Avenue, Cardiff, CF23 8RU · collab

RandomizedParallel-groupDouble-blindBasic science

Summary

This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.

Timeline

Start: 2026-05-01
Primary completion: 2026-11
Completion: 2026-11

Publications

Background Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022 Nov;37(6):e2852. doi: 10.1002/hup.2852. Epub 2022 Jul 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pyridoxal 5'-Phosphate	Unknown	100 mg	—

The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

Summary

Timeline

Publications

Drugs

Indications