Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser

Phase 2 Recruiting 36 enrolled Misr University for Science and Technology

RandomizedParallel-groupTriple-blindTreatment

Summary

Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.

Timeline

Start: 2026-03-01
Primary completion: 2026-07-01
Completion: 2026-07-01

Publications

Background Kim JH, Jeong JJ, Lee YI, Lee WJ, Lee C, Chung WY, Nam KH, Lee JH. Preventive effect of polynucleotide on post-thyroidectomy scars: A randomized, double-blinded, controlled trial. Lasers Surg Med. 2018 Mar 25. doi: 10.1002/lsm.22812. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Polydeoxyribonucleotide	Unknown	—	Other

Indications

No indication recorded.