drugset / Trial / NCT07490769

Levetiracetam Three Times Daily in Epilepsy

NCT07490769

Phase 3 Recruiting 120 enrolled Waad Alkathiri
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this clinical trial is to evaluate the efficacy and tolerability of Levetiracetam administered three times daily in patients with epilepsy. The primary objective is to investigate whether orally administered Levetiracetam three times daily dosing is superior in seizure-free days compared to standard twice-daily dosing in patients with epilepsy. Key questions include: * Does LEV improve seizure control, as measured by seizure-free days? * What adverse events or safety concerns are observed with LEV treatment? Participants will receive Levetiracetam administered three times daily during the treatment phase. The study will use a self-matched, pre-post design in which each participant serves as their own control. Baseline seizure activity and safety data will be collected prior to LEV initiation and compared with data obtained during the treatment period. Participants will attend scheduled clinic visits for efficacy and safety evaluations and will maintain a daily diary to record seizure frequency and any treatment-related events.

Timeline

Start
2025-10-01
Primary completion
2028-12-30
Completion
2028-12-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Levetiracetam Other / unclassified 500 mg Oral
Comparator Levetiracetam Other / unclassified 750 mg Oral
Comparator Levetiracetam Other / unclassified 1000 mg Oral
Comparator Levetiracetam Other / unclassified 1500 mg Oral

Indications