drugset
drugset / Trial / NCT07494214

Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants

NCT07494214 ↗

Phase 1 Recruiting 20 enrolled University Hospital, Basel, Switzerland
RandomizedCrossoverTriple-blindBasic science

Summary

This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect). In the study, moderate pain will be artificially created in healthy participants using repeated small electrical pulses applied under the skin. At the same time, participants will take MDMA or a placebo by mouth. This allows researchers to compare how MDMA affects the artificially created pain. A total of 20 healthy volunteers will take part in this study.

Timeline

Start
2026-03-09
Primary completion
2027-03-09
Completion
2027-04-09

Drugs

EvaluationDrugModalityDoseRoute
Subject 3,4-methylenedioxymethamphetamine Unknown 25 mg Oral
Subject 3,4-methylenedioxymethamphetamine Unknown 75 mg Oral
Subject 3,4-methylenedioxymethamphetamine Unknown 125 mg Oral

Indications

No indication recorded.