MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity

Summary

This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity. Participants are randomized 1:1 to MOTS-c or placebo, receive standardized lifestyle counseling, and are followed for safety through Week 16.

Timeline

Start

2026-02-02

Primary completion

2027-02-14

Completion

2028-05-17

Drugs

Indications