drugset / Trial / NCT07515469

A Prospective, Single-Arm, Exploratory Study of the Safety and Efficacy of Neoadjuvant Treatment With QL1706, an Anti-PD-1/Anti-CTLA-4 Bispecific Antibody, in Resectable Stage IB and IIA Hepatocellular Carcinoma With High Recurrence Risk

NCT07515469

Phase 2 Not yet recruiting 30 enrolled Tianjin Medical University Cancer Institute and Hospital
NaSingle-groupOpen-labelTreatment

Summary

This study aims to investigate the efficacy and safety of neoadjuvant therapy with Iparomlimab and Tuvonralimab Injection (anti-PD-1 and anti-CTLA-4 antibody combination) in patients with resectable hepatocellular carcinoma at high risk of recurrence (Stage IB, Stage IIA).

Timeline

Start
2026-05-30
Primary completion
2028-05-30
Completion
2030-10-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Iparomlimab Monoclonal antibody Intravenous
Subject Tuvonralimab Monoclonal antibody Intravenous