Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder

Summary

This study will look at how a new medication (dextromethorphan and bupropion taken together in one pill) affects the brain in people with depression. All participants will take the medication for two weeks and have brain scans done. Since people with depression often feel reduced enjoyment in day-to-day activities, our goal is to learn if this treatment can change brain activities in ways that could help improve mood and enjoyment in life.

Timeline

Start

2025-11-21

Primary completion

2026-07

Completion

2027-01

Drugs

Indications