Efficacy and Safety of Lifei Qingchang Granules for Stable Bronchiectasis
Summary
The purpose of this study is to evaluate the efficacy and safety of Lifei Qingchang Granules in the treatment of patients with stable bronchiectasis. This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. Researchers plan to enroll a total of 150 adult participants (aged 18-75) who have been diagnosed with stable bronchiectasis and experience at least one acute exacerbation in the past 12 months. Participants will be randomly assigned into two groups in a 1:1 ratio: * The treatment group will receive Lifei Qingchang Granules along with standard postural drainage therapy. * The control group will receive a matching placebo along with standard postural drainage therapy. The treatment period will last for 3 months. The main goal is to see if the treatment can improve patients' respiratory symptoms and overall quality of life.
Timeline
- Start
- 2026-04
- Primary completion
- 2028-03
- Completion
- 2028-04
Publications
- Results Yuanlong H, Wanyan L, Jiamin Z, Shangke G, Yingsi D, Ran L, Zhu L, Shiting D, Min H, Zhiming P, Qifen H, Zhijuan W, Xinghua S, Shouxie H, Zhenqiu L, Dapeng Z, Wenju L, Zhimin Z. Lifei Qingchang Granules alleviate airway inflammation in a mouse model of bronchiectasis by inhibiting neutrophil extracellular traps. J Ethnopharmacol. 2026 Feb 10;356:120855. doi: 10.1016/j.jep.2025.120855. Epub 2025 Nov 4.
- Results Huang QF, Zeng JM, Hu YL, Li WY, Yu QH, Wang P, Ren PH, Peng Y, Guan WJ, Lin R, Li ZQ, Tan WL, Zhu HP, Huang SX, Zhang DP, Jie ZC, Wu ZJ, Zhang ZM. Lifei Qingchang Tang attenuates acute lung injury via the NF-kappaB and MAPK signaling pathways. J Asian Nat Prod Res. 2025 Nov;27(11):1690-1705. doi: 10.1080/10286020.2025.2473648. Epub 2025 Mar 12.
- Results Zhang ZM, Ren PH, Wu ZJ, Zhang DP, Xie WJ. Personalized alternative therapy of intractable bronchiectasis-induced hemoptysis in a patient: syndrome differentiation and treatment according to individual physique category. J Thorac Dis. 2013 Jun;5(3):E115-7. doi: 10.3978/j.issn.2072-1439.2013.06.26. No abstract available.
- Results Zhang ZM, Ren PH, Guan WJ. Symptom-based treatment with Traditional Chinese Medicine in bronchiectasis patients with hemoptysis. J Thorac Dis. 2017 Sep;9(9):E884-E886. doi: 10.21037/jtd.2017.08.170. No abstract available.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lifei Qingchang Granules | Traditional medicine (herbal / TCM) | 1 unknown | Oral |