Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy

Summary

Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality. Participants will: * Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result * Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively * Undergo a visual analog scale for analgesia status at 6 hours postoperatively

Timeline

Start

2026-04

Primary completion

2026-09

Completion

2026-09

Publications

• Background Turk B, Akpinar M, Erol ZN, Kaya KS, Unsal O, Coskun BU. The effect of flurbiprofen oral spray and ibuprofen vs ibuprofen alone on postoperative tonsillectomy pain: An open, randomised, controlled trial. Clin Otolaryngol. 2018 Jun;43(3):835-840. doi: 10.1111/coa.13058. Epub 2018 Jan 18.
• Background Muderris T, Tezcan G, Sancak M, Gul F, Ugur G. Oral flurbiprofen spray for postoperative sore throat and hoarseness: a prospective, randomized, double-blind, placebo-controlled study. Minerva Anestesiol. 2019 Jan;85(1):21-27. doi: 10.23736/S0375-9393.18.12703-9. Epub 2018 May 14.

Drugs

Indications