VENEZE Peptide Factor Hair Serum Compared With Topical 2% Minoxidil for Androgenetic Alopecia

Summary

This study aims to evaluate the effectiveness and tolerability of a peptide-based hair serum compared with topical minoxidil in patients with androgenetic alopecia. Participants will be randomly assigned, in a double-blind manner, to receive either the peptide hair serum or topical minoxidil. The primary objective is to assess improvement in hair growth over the study period, including changes in hair density and hair thickness. Secondary outcomes will include safety and tolerability assessments. The findings of this study may provide evidence supporting an alternative treatment option for patients with androgenetic alopecia.

Timeline

Start

2026-05-05

Primary completion

2026-11-30

Completion

2026-11-30

Publications

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• Results Penha MA, Miot HA, Kasprzak M, Muller Ramos P. Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial. JAMA Dermatol. 2024 Jun 1;160(6):600-605. doi: 10.1001/jamadermatol.2024.0284.
• Results Olsen EA, Whiting D, Bergfeld W, Miller J, Hordinsky M, Wanser R, Zhang P, Kohut B. A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2007 Nov;57(5):767-74. doi: 10.1016/j.jaad.2007.04.012. Epub 2007 Aug 29.
• Results Truong VL, Jeong WS. Hair growth-promoting mechanisms of red ginseng through Wnt/β-catenin. Plants (Basel). 2021;10(10):2067.
• Results Fang C, Chen Y, Zhao L, Huang Y, Li J, Xu Y, et al. Ginsenoside CK inhibits androgenetic alopecia by regulating dihydrotestosterone and Wnt/β-catenin in mice. Food Front. 2023;4(1):96-108.
• Results Jeong G, Kim H, Ahn J, Yoon J, Lee J, Cho AR, et al. Ginsenoside Re prevents catagen by activating autophagy and Wnt/β-catenin in human dermal papilla cells. Int J Mol Sci. 2022;23(9):4885.
• Results Zhang B, Zhang W, Luo J, He J, Zheng X, Zhu S, Rong B, Ai Y, Zhang L, He T. Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines. J Appl Biomed. 2023 Apr;21(1):48-57. doi: 10.32725/jab.2023.003. Epub 2023 Mar 27.
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• Results Voiculescu VM, Raducan A, Popa LG, Cretu A, Draghici CC, Voinescu DC, et al. Comparative study of a topical and oral combination (Minoxicapil) in androgenetic alopecia: a 3-month clinical study. Cosmetics (Basel). 2025;12(4):152.
• Results Thom E. Pregnancy and the hair growth cycle: anagen induction against hair growth disruption using Nourkrin(R) with Marilex(R) , a proteoglycan replacement therapy. J Cosmet Dermatol. 2017 Sep;16(3):421-427. doi: 10.1111/jocd.12286. Epub 2016 Sep 23.
• Results Thom E, Wadstein J. Treating female diffuse hair loss using Nourkrin® Woman (with Marilex®) - an open-label, subjective, outcome study on hair growth and appearance, self-confidence and treatment satisfaction. J Clin Dermatol Ther. 2019;5:037.
• Results Couchman JR. Hair follicle proteoglycans. J Invest Dermatol. 1993 Jul;101(1 Suppl):60S-64S. doi: 10.1111/1523-1747.ep12362642.
• Results Lucky AW, Piacquadio DJ, Ditre CM, Dunlap F, Kantor I, Pandya AG, Savin RC, Tharp MD. A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol. 2004 Apr;50(4):541-53. doi: 10.1016/j.jaad.2003.06.014.
• Results Shin HS, Park SY, Choi JS, Park JS, Lee JH. Promotion of hair growth by ginsenoside-Rb1 through dermal papilla cell proliferation and Wnt/β-catenin signaling. Phytother Res. 2014;28(12):1873-9.
• Results Harada N, Okajima K, Arai M, Kurihara H, Nakagata N. Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. Growth Horm IGF Res. 2007 Oct;17(5):408-15. doi: 10.1016/j.ghir.2007.04.009. Epub 2007 Jun 13.
• Results Tr P, Ts R, K SK, Prasanna H. A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia. Cureus. 2023 May 8;15(5):e38696. doi: 10.7759/cureus.38696. eCollection 2023 May.
• Results Drake L, Hordinsky M, Fiedler V, Swinehart J, Unger WP, Cotterill PC, Thiboutot DM, Lowe N, Jacobson C, Whiting D, Stieglitz S, Kraus SJ, Griffin EI, Weiss D, Carrington P, Gencheff C, Cole GW, Pariser DM, Epstein ES, Tanaka W, Dallob A, Vandormael K, Geissler L, Waldstreicher J. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999 Oct;41(4):550-4.
• Results Gupta AK, Talukder M, Williams G. Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia. J Dermatolog Treat. 2022 Nov;33(7):2946-2962. doi: 10.1080/09546634.2022.2109567. Epub 2022 Aug 15.
• Results Whiting DA. Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss. J Am Acad Dermatol. 2001 Sep;45(3 Suppl):S81-6. doi: 10.1067/mjd.2001.117428.
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