Antihistamine for Prevention of HTR After Blood Primed CPB

Phase 4 Recruiting 40 enrolled Kasr El Aini Hospital Misr University for Science and Technology · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.

Timeline

Start: 2026-03-01
Primary completion: 2026-11
Completion: 2026-12

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chlorpheniramine	Unknown	0.25 mg/kg	Intravenous

Indications

No indication recorded.