drugset
drugset / Trial / NCT07548385

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

NCT07548385 ↗

Phase 3 Recruiting 235 enrolled Icahn School of Medicine at Mount Sinai
RandomizedParallel-groupTriple-blindTreatment

Summary

This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery? 2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.

Timeline

Start
2026-04
Primary completion
2027-02-23
Completion
2027-02-23

Drugs

EvaluationDrugModalityDoseRoute
Subject Suzetrigine Small molecule 50 mg —

Indications

No indication recorded.