drugset / Trial / NCT07556718
Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease
Phase 2
Recruiting
100 enrolled
University of Michigan
The Leona M. and Harry B. Helmsley Charitable Trust · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled. Amitriptyline is a medication commonly used at low doses to treat irritable bowel syndrome (IBS) and abdominal pain. This study will assess whether amitriptyline is safe and reduces those ongoing GI symptoms in adults with Crohn's disease in remission.
Timeline
- Start
- 2026-06-03
- Primary completion
- 2029-12
- Completion
- 2029-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amitriptyline | Small molecule | 50 mg | Oral |