Psilocybin Administration With 5-HT1a Blockade

Phase 0 Recruiting 18 enrolled Johns Hopkins University

RandomizedCrossoverTriple-blindBasic science

Summary

The purpose of this study is to assess the effects of 5-HT1A receptor blockade on the acute subjective effects of psilocybin, as measured through subjective survey measures and acute electroencephalography (EEG). Further, the investigators will assess the effects of psilocybin on post-acute sleep and dreaming through the use of sleep EEG and sleep and dream diaries.

Timeline

Start: 2026-08-01
Primary completion: 2028-06-15
Completion: 2028-06-15

Publications

Background Strassman RJ. Human psychopharmacology of N,N-dimethyltryptamine. Behav Brain Res. 1996;73(1-2):121-4. doi: 10.1016/0166-4328(96)00081-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pindolol	Small molecule	30 mg	—
Subject	Psilocybin	Other / unclassified	18 mg	—

Indications

No indication recorded.