drugset / Trial / NCT07569029
A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies
Phase 1
Not yet recruiting
42 enrolled
National Institute of Allergy and Infectious Diseases (NIAID)
Department of Health and Human Services · collabDuke University · collab
Non-randomizedSequentialOpen-labelBasic science
Summary
This phase 1 study will evaluate the safety, tolerability, and immune responses of two experimental mRNA HIV vaccines in adults living with HIV who are in overall good health. The study will enroll about 42 participants at multiple study sites. Researchers will assess whether these vaccines can start or strengthen antibody responses against HIV. The study will also evaluate how a closely monitored planned pause in antiretroviral therapy affects these immune responses.
Timeline
- Start
- 2026-06-02
- Primary completion
- 2027-08-31
- Completion
- 2027-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | DV700P-RNA | Vaccine | 100 ug | Intramuscular |
| Subject | DV701B1.1-RNA | Vaccine | 100 ug | Intramuscular |