drugset / Trial / NCT07569263
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases
NaSingle-groupOpen-labelTreatment
Summary
This is a Phase I Study evaluating the safety and feasibility of IL-8 receptor-modified patient-derived activated CD70 CAR T cells in adult patients with brain metastases from primary cancer, with either newly diagnosed lesions or recurrent or progressive disease after prior therapy.
Timeline
- Start
- 2026-07
- Primary completion
- 2029-12
- Completion
- 2044-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 8R-70CAR T cells | Cell therapy | 1e+07 cells/kg | Intravenous |
| Subject | 8R-70CAR T cells | Cell therapy | 1e+08 cells/kg | Intravenous |