drugset / Trial / NCT07575945

A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medicine PF-08642534 in Healthy Adults.

NCT07575945

Phase 1 Active not recruiting 14 enrolled Pfizer
Non-randomizedSequentialOpen-labelBasic science

Summary

The purpose of this study is to learn if a medicine called itraconazole changes how the body processes the study medicine (PF-08642534) in healthy adults. This study is seeking healthy participants (men or women) who: * are aged 18 to 65 years of age * are confirmed to be healthy by their medical history and medical tests * have body mass index (BMI) of 16 to 30 kilograms per meter squared * have a total body weight of more than 50 kilograms. Participants will receive single doses of the study medicine (PF-08642534) with and without itraconazole. The total planned time of participation is about 12 weeks. The study consists of: * a screening period of up to 28 days before taking study drug * about 4 weeks of staying in the study clinic * a follow-up contact that will occur 28 to 35 days after taking itraconazole the last time.

Timeline

Start
2026-05-05
Primary completion
2026-06-26
Completion
2026-07-23

Drugs

EvaluationDrugModalityDoseRoute
Subject Itraconazole Small molecule
Subject PF-08642534 Unknown Oral

Indications

No indication recorded.